
Cataloguenumber
ANT-702
Synonyms
RAB7AmemberRASoncogenefamily,RAB7,ras-relatedproteinRab-7a,FLJ20819,PSN,CMT2B,PRO2706.
Type
Introduction
RAB7AbelongstotheRassuperfamilyofsmallRabGTPases.RAB7AconnectswiththeRIPLeffectorproteintoregulatormembranetraffickingfromearlytolateendosomeandtolysosomes.RAB7Acanalsoregulategrowthreceptorendocytictrafficking,degradation,maturationofphagosomeandautophagicvacuoles.
Clone
PAT10E4AT.
PhysicalAppearance
Immunogen
Anti-humanRAB7AmAb,isderivedfromhybridizationofmouseF0myelomacellswithspleencellsfromBALB/cmiceimmunizedwitharecombinanthumanRAB7Aprotein1-207aminoacidspurifiedfromE.coli.
IgSubclass
MouseIgG2aheavychainandklightchain.
PurificationMethod
RAB7Aantibodywaspurifiedfrommouseasciticfluidsbyprotein-Aaffinitychromatography.
Formulation
1mg/mlcontainingPBS,pH-7.4,10%Glyceroland0.02%SodiumAzide.
StorageProcedures
StABIlity/ShelfLife
Applications
RAB7AantibodyhasbeentestedbyELISAandWesternblotanalysistoassurespecificityandreactivity.Sinceapplicationvaries,however,eachinvestigationshouldbetitratedbythereagenttoobtainoptimalresults.