
Cataloguenumber
ANT-704
Synonyms
Peptidyl-prolylcis-transisomeraseD,PPIaseD,40kDapeptidyl-prolylcis-transisomerase,Cyclophilin-40,CYP-40,Cyclophilin-relatedprotein,CYP40,CYPD,PPID,PeptidylprolylIsomeraseD.
Type
Introduction
Cyclophilin-Disamemberofthepeptidyl-prolylcis-transisomerase(PPIase)family.PPIasescatalyzethecis-transisomerizationofprolineimidicpeptidebondsinoligopeptidesandspeedsuptheproteinfolding.Cyclophilin-DpossessPPIaseactivityandbindstotheimmunosuppressantcyclosporin-A.Cyclophilin-Disverywellknownthatitsoverexpressionsuppressestheapoptosisincancercell.Cyclophilin-Dsuppressesapoptoticcelldeathbytheuseofmitochondrialhexokinase-2dependentmechanismincancercells.
Clone
PAT1B8AT.
PhysicalAppearance
Immunogen
Anti-humanPPIDmAb,isderivedfromhybridizationofmouseF0myelomacellswithspleencellsfromBALB/cmiceimmunizedwithrecombinanthumanPPIDaminoacids1-370purifiedfromE.coli.
IgSubclass
MouseIgG2bheavychainandκlightchain.
PurificationMethod
PPIDantibodywaspurifiedfrommouseasciticfluidsbyprotein-Aaffinitychromatography.
Formulation
1mg/mlcontainingPBS,pH-7.4,10%Glyceroland0.02%SodiumAzide.
StorageProcedures
StABIlity/ShelfLife
Applications
PPIDantibodyhasbeentestedbyELISAandWesternblotanalysistoassurespecificityandreactivity.Sinceapplicationvaries,however,eachinvestigationshouldbetitratedbythereagenttoobtainoptimalresults.