
Cataloguenumber
PRO-2449
Synonyms
Syndecan2,HeparanSulfateProteoglycan1CellSurface-Associated,HeparanSulfateProteoglycanCoreProtein,SyndecanProteoglycan2,Fibroglycan,HSPG1,SYND2,HSPG,CellSurface-AssociatedHeparanSulfateProteoglycan1,CD362Antigen,Syndecan-2,CD362,SDC2.
Introduction
Syndecan2(SDC2)isaconservedfamilyofheparan-andchondroitin-sulfatecarryingtransmembraneprotein.Syndecan2isacellmembraneproteoglycanwhichmodulatestheactivityanddynamicsofsomegrowthfactorreceptorsandintegrins.SDC2isexpressedinHSCs(hepaticstellatecells),akeycelltypeinvolvedinmatrixdepositioninliverfibroticdisorders.SDC2isimplicatedintheformationofspecializedmembranedomainsandservesasadirectlinkbetweentheextracellularenvironmentandtheorganizationofthecorticalcytoplasm.
Description
SDC2HumanRecombinantproducedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining135aminoacids(19-144a.a.)andhavingamolecularmassof15kDa(MolecularsizeonSDS-PAGEwillappearatapproximately18-28kDa).SDC2isexpressedwitha6aminoacidsHistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
Sf9,Baculoviruscells.
PhysicalAppearance
Formulation
SDC2proteinsolution(0.25mg/ml)containsPhosphateBufferedSaline(pH7.4)and10%glycerol.
StABIlity
Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).
Avoidmultiplefreeze-thawcycles.
Purity
Greaterthan90.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
ADPESRAELTSDKDMYLDNSSIEEASGVYPIDDDDYASASGSGADEDVESPELTTSRPLPKILLTSAAPKVETTTLNIQNKIPAQTKSPEETDKEKVHLSDSERKMDPAEEDTNVYTEKHSDSLFKRTEHHHHHH.