Cataloguenumber
PRO-2450
Synonyms
SialicAcidBindingIgLikeLectin6,Obesity-BindingProtein1,CD33Antigen-Like1,CDW327,CD33L1,CD33L,OBBP1,SialicAcidBindingIg-LikeLectin6,SialicAcid-BindingIg-LikeLectin6,CD327Antigen,Siglec-6,CD33L2,OB-BP1,CD327,SIGLEC6.
Introduction
Sialicacid-bindingIg-likelectin6isoform1(SIGLEC6)isamemberofimmunoglobulinsuperfamilyandSIGLEC(sialicacidbindingIg-likelectin)family.SIGLEC6mediatessialic-aciddependentbindingtocellsandbindstoalpha-2,6-linkedsialicacid.TheSIGLEC6proteinlocalizesinnumerouscompartmentssuchasmembranefraction,extracellularregionandsoon.TheSIGLEC6receptorbindssialyl-TNglycansandleptin.PlacentalexpressionSIGLEC6isupregulatedinpreeclampsia.
Description
SIGLEC6HumanRecombinantproducedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining563aminoacids(27-347a.a.)andhavingamolecularmassof62.6kDa(MolecularsizeonSDS-PAGEwillappearatapproximately70-100kDa).SIGLEC6isexpressedwitha239aminoacidshIgG-HistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
Sf9,Baculoviruscells.
PhysicalAppearance
Formulation
SIGLEC6proteinsolution(0.5mg/ml)containsPhosphateBufferedSaline(pH7.4)and10%glycerol.
StABIlity
Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).
Avoidmultiplefreeze-thawcycles.
Purity
Greaterthan90.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
ADLQERRFQLEGPESLTVQEGLCVLVPCRLPTTLPASYYGYGYWFLEGADVPVATNDPDEEVQEETRGRFHLLWDPRRKNCSLSIRDARRRDNAAYFFRLKSKWMKYGYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQGTPPIFSWMSAAPTSLGPRTTQSSVLTITPRPQDHSTNLTCQVTFPGAGVTMERTIQLNVSYAPQKVAISIFQGNSAAFKILQNTSSLPVLEGQALRLLCDADGNPPAHLSWFQGFPALNATPISNTGVLELPQVGSAEEGDFTCRAQHPLGSLQISLSLFVHWKPEGRAGGVLEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH.
