Cataloguenumber
PRO-2447
Synonyms
SialicAcidBindingIgLikeLectin9,ProteinFOAP-9,Siglec-9,CDw329,SialicAcidBindingIg-LikeLectin9,SialicAcid-BindingIg-LikeLectin9,CD329Antigen,OBBP-LIKE,FOAP-9,CD329.
Introduction
SialicAcidBindingIgLikeLectin9(SIGLEC9)isamemberofthesialicacid-bindingIg-likelectinfamily,whichisapartoftheimmunoglobulinsuperfamilyexpressedmostlyonhumanbloodleukocytes.SIGLEC9isaPutativeadhesionmoleculewhichisexpressedinbonemarrow,placenta,spleen,andfetalliver.SIGLEC9isalsoapartoftherecentlycharacterizedCD33-relatedSiglecfamilyofsialicacidbindingprotein.
Description
SIGLEC9HumanRecombinantproducedinSf9Insectcellsisasingle,glycosylatedpolypeptidechaincontaining573aminoacids(18-348a.a.)andhavingamolecularmassof63.3kDa(MolecularsizeonSDS-PAGEwillappearatapproximately70-100kDa).
SIGLEC9isexpressedwitha239aminoacidshIgG-HistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
SIGLEC9proteinsolution(0.5mg/ml)containsPhosphateBufferedSaline(pH7.4)and10%glycerol.
StABIlity
Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).
Avoidmultiplefreeze-thawcycles.
Purity
Greaterthan95.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
ADPQTSKLLTMQSSVTVQEGLCVHVPCSFSYPSHGWIYPGPVVHGYWFREGANTDQDAPVATNNPARAVWEETRDRFHLLGDPHTKNCTLSIRDARRSDAGRYFFRMEKGSIKWNYKHHRLSVNVTALTHRPNILIPGTLESGCPQNLTCSVPWACEQGTPPMISWIGTSVSPLDPSTTRSSVLTLIPQPQDHGTSLTCQVTFPGASVTTNKTVHLNVSYPPQNLTMTVFQGDGTVSTVLGNGSSLSLPEGQSLRLVCAVDAVDSNPPARLSLSWRGLTLCPSQPSNPGVLELPWVHLRDAAEFTCRAQNPLGSQQVYLNVSLQSKATSGVTQGLEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH.
