
Cataloguenumber
PRO-2438
Synonyms
ProteasomalubiquitinreceptorADRM1,110kDacellmembraneglycoprotein,Gp110,Adhesion-regulatingmolecule1,ARM-1,Proteasomeregulatoryparticlenon-ATPase13,hRpn13,Rpn13homolog,ADRM1,ARM1,Rpn13.
Introduction
Protein-cReceptor(PROCR)isareceptorforactivatedproteinC,aserineproteaseactivatedbyandinvolvedinthebloodcoagulationpathway.ThePROCRproteinisanN-glycosylatedtypeImembraneproteinwhichenhancestheactivationofproteinC.PROCRgenemutationsarelinkedwithvenousthromboembolismandmyocardialinfarction,aswellaswithlatefetallossduringpregnancy.Inaddition,PROCRmayhavearoleinmalarialinfectionandhasbeenlinkedwithcancer.
Description
PROCRHumanRecombinantproducedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining435aminoacids(18-210a.a.)andhavingamolecularmassof49.3kDa(MolecularsizeonSDS-PAGEwillappearatapproximately40-57kDa).PROCRisexpressedwitha242aminoacidshIgG-HistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
Sf9,Baculoviruscells.
PhysicalAppearance
Formulation
PROCRproteinsolution(0.5mg/ml)containsPhosphateBufferedSaline(pH7.4)and10%glycerol.
StABIlity
Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).
Avoidmultiplefreeze-thawcycles.
Purity
Greaterthan95.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
ADPSQDASDGLQRLHMLQISYFRDPYHVWYQGNASLGGHLTHVLEGPDTNTTIIQLQPLQEPESWARTQSGLQSYLLQFHGLVRLVHQERTLAFPLTIRCFLGCELPPEGSRAHVFFEVAVNGSSFVSFRPERALWQADTQVTSGVVTFTLQQLNAYNRTRYELREFLEDTCVQYVQKHISAENTKGSQTSRSYTSLEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH.