Cataloguenumber
PRO-2451
Synonyms
ImmunoglobulinSuperfamilyMember8,Keratinocytes-AssociatedTransmembraneProtein4,Glu-Trp-IleEWIMotif-ContainingProtein2,ProstaglandinRegulatory-LikeProtein,CD81Partner3,CD81P3,LIR-D1,EWI-2,KCT-4,EWI2,PGRL,ImmunoglobulinSuperfamilyMember8,CD316Antigen,CD316,IgSF8,KCT4.
Introduction
Immunoglobulinsuperfamilymember8(IGSF8)belongstotheimmunoglobulinproteinsuperfamily.IGSF8interactswiththetetraspaninsCD81andCD9andmayregulatetheirroleinanumberofcellularfunctionsincludingcellmigrationandviralinfection.Inaddition,theIGSF8proteinmayfunctionasatumorsuppressorbyinhibitingtheproliferationofcertaincancers.
Description
IGSF8HumanRecombinantproducedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining561aminoacids(28-579a.a.)andhavingamolecularmassof59.6kDa(MolecularsizeonSDS-PAGEwillappearatapproximately50-70kDa).IGSF8isexpressedwitha6aminoacidsHistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
Sf9,Baculoviruscells.
PhysicalAppearance
Formulation
IGSF8proteinsolution(0.5mg/ml)containsPhosphateBufferedSaline(pH7.4)and30%glycerol.
StABIlity
Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).
Avoidmultiplefreeze-thawcycles.
Purity
Greaterthan95.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
ADLREVLVPEGPLYRVAGTAVSISCNVTGYEGPAQQNFEWFLYRPEAPDTALGIVSTKDTQFSYAVFKSRVVAGEVQVQRLQGDAVVLKIARLQAQDAGIYECHTPSTDTRYLGSYSGKVELRVLPDVLQVSAAPPGPRGRQAPTSPPRMTVHEGQELALGCLARTSTQKHTHLAVSFGRSVPEAPVGRSTLQEVVGIRSDLAVEAGAPYAERLAAGELRLGKEGTDRYRMVVGGAQAGDAGTYHCTAAEWIQDPDGSWAQIAEKRAVLAHVDVQTLSSQLAVTVGPGERRIGPGEPLELLCNVSGALPPAGRHAAYSVGWEMAPAGAPGPGRLVAQLDTEGVGSLGPGYEGRHIAMEKVASRTYRLRLEAARPGDAGTYRCLAKAYVRGSGTRLREAASARSRPLPVHVREEGVVLEAVAWLAGGTVYRGETASLLCNISVRGGPPGLRLAASWWVERPEDGELSSVPAQLVGGVGQDGVAELGVRPGGGPVSVELVGPRSHRLRLHSLGPEDEGVYHCAPSAWVQHADYSWYQAGSARSGPVTVYPYMHALDTHHHHHH.
