Prospec/GM2AP1 Human/PRO-2289/1mg
商品编号：
PRO-2289
品牌：
prospecbio
市场价：
¥104000.00
美元价：
44200.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Catalogue number
PRO-2289
Synonyms
GM2 Ganglioside Activator, Cerebroside Sulfate Activator Protein, Sphingolipid Activator Protein 3, GM2-AP, SAP-3, GM2 Ganglioside Activator Protein, Shingolipid Activator Protein 3, GM2A.
Introduction
GM2 Ganglioside Activator Pseudogene 1 (GM2AP1) is a small glycolipid transport protein which functions as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, along with GM2AP1, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. GM2AP1 protein is localized in lysosomes. GM2AP1 participates in lipid metabolism. GM2AP1 protein forms a large binding pocket for a number of single chain phospholipids and fatty acids. GM2AP1 displays calcium-independent phospholipase activity. GM2AP1 stimulates ganglioside GM2 degradation by presenting GM2 to beta-hexosaminidase A. GM2AP1 gene mutations result in GM2-gangliosidosis type AB or the AB variant of Tay-Sachs disease.
Description
GM2AP1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (Ser33-Ile193) containing 170 amino acids including a 9 aa His tag at N-terminus. The total calculated molecular mass is 18.7kDa.
Source
Escherichia Coli.
Physical Appearance
Filtered White lyophilized (freeze-dried) powder.
Formulation
GM2AP1 was filtered (0.4µm) and lyophilized from 0.5mg/ml in 0.05M Tris buffer and 0.1M NaCl, pH 8.0.
Solubility
It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. GM2AP1 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Stability
Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
Amino acid sequence
MKHHHHHHAS FSWDNCDEGK DPAVIRSLTL EPDPIIVPGN VTLSVMGSTS VPLSSPLKVD LVLEKEVAGL WIKIPCTDYI GSCTFEHFCD VLDMLIPTGE PCPEPLRTYG LPCHCPFKEG TYSLPKSEFV VPDLELPSWL TTGNYRIESV LSSSGKRLGC IKIAASLKGI.
Purity
Greater than 95.0% as determined by SDS-PAGE.
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
品牌介绍
ProSpec-Tany TechnoGene Ltd.公司创立人Dr. Tanchum (Tany) Amarant 主要致力于蛋白生物化学方面的研究工作，1947年出生于以色列。1991-1997创建ReProGen 公司，从事细胞因子和趋化因子的大量生产及纯化；1997-2000创建ProSpec-TechnoGene，主要生产用于生命科学研究的各种重组蛋白及相关抗体。拥有专利United States Patent 5434135。
ProSpec is an evolving biotech company providing highly purified proteins worldwide which serve the research community with cytokine-related products for cancer, apoptosis, development, endocrinology, immunology, neuroscience, proteases, and stem cell research.
Among our proteins are Interferons, Interleukins, Bone Morphogenic Proteins, Tumor Necrosis factors, Leptins, Stem Cell factors, Prolactins, Chemokines, Antibodies, Peptides, Enzymes, Viral Antigens, various growth factors such as: Platelet Derived, Epidermal, Insulin Like, Nerve, Connective Tissue, Vascular Endothelial, Fibroblast and more.....
Our research team and scientists have been able to assemble more than 1700 recombinant proteins, peptides and antibodies for your research needs. The proteins are rigorously tested to meet the research and development demand for excellent quality, uncompromising biological activity at competitive prices.
ProSpec has established sterling reputation among the scientific community, a reputation built on innovative products, customer service and attention to detail. Our reputation for quality is an essential factor in achieving a favorable position in the market place and the benefits associated with manufacturing top quality products.
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