
Cataloguenumber
PRO-2389
Synonyms
FolateReceptor1,OvarianTumor-AssociatedAntigenMOv18,AdultFolate-BindingProtein,FolateReceptor1(Adult),FolateReceptorAdult,FolateReceptorAlpha,KBCellsFBP,FR-Alpha,FOLR,FBP,FolateBindingProtein,FOLR1.
Introduction
FolateReceptor1,alsoknownasFOLR1,isapartofthefolatereceptorfamilywhosemembersbindfolicacid.FOLR1bindstofolateandreducedfolicacidderivativesandfacilitatestransferof5-methyltetrahydrofolateandfolateanalogsintothecells.FOLR1iseitherattachestomembranesthroughaglycosyl-phosphatidylinositollinkageorexistsinasolubleform.FOLR1isalsoneededforembryonicdevelopmentandnormalcellproliferation.
Description
FOLR1HumanRecombinantproducedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining218aminoacids(26-234a.a.)andhavingamolecularmassof25.6kDa(MolecularsizeonSDS-PAGEwillappearatapproximately28-40kDa).
FOLR1isexpressedwitha6aminoacidHistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
FOLR1proteinsolution(0.25mg/ml)containsPhosphateBufferedSaline(pH7.4)and10%glycerol.
StABIlity
Purity
Greaterthan90.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
ADLIAWARTELLNVCMNAKHHKEKPGPEDKLHEQCRPWRKNACCSTNTSQEAHKDVSYLYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPWIQQVDQSWRKERVLNVPLCKEDCEQWWEDCRTSYTCKSNWHKGWNWTSGFNKCAVGAACQPFHFYFPTPTVLCNEIWTHSYKVSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAAAMSHHHHHH.