Catalogue number
PRO-2398
Synonyms
Chorionic Gonadotropin Beta Subunit 3, Chorionic Gonadotropin, Beta Polypeptide, Chorionic Gonadotropin Chain Beta, CG-Beta, CGB, Chorionic Gonadotropin Beta 3 Subunit, Chorionic Gonadotropin Beta Subunit, Chorionic Gonadotrophin Chain Beta, Chorionic Gonadotropin Beta Chain, CGB3 CGB5 CGB8, CGB5, CGB7, CGB8, HCGB, CG-beta, Chorionic gonadotropin chain beta.
Introduction
Chorionic Gonadotropin Beta Subunit 3, also known as CGB3, belongs to the glycoprotein hormone beta chain family. CGB3 encodes the beta 3 subunit of chorionic gonadotropin (CG). CGB3 stimulates the expression of GCM1 target genes, as well as the fusogenic protein syncytin-1, to promote placental cell fusion. Furthermore, CGB3 is synthesized in large quantities by the growing placenta, reaching peak concentrations in maternal blood throughout the late first trimester and early mid-trimester of pregnancy. CGB3 is expressed solely by trophoblasts. CGB3 is a significant biomarker in pregnancy and oncology, where it is routinely detected and quantified by specific immunoassays.
Description
CGB3 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 154 amino acids (21-165.a.) and having a molecular mass of 16.6kDa (Molecular size on SDS-PAGE will appear at approximately 18-28kDa). CGB3 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Source
Sf9, Baculovirus cells.
Physical Appearance
Formulation
CGB3 protein solution (0.25mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Stability
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Purity
Amino acid sequence
ADPSKEPLRP RCRPINATLA VEKEGCPVCI TVNTTICAGY CPTMTRVLQG VLPALPQVVC NYRDVRFESI RLPGCPRGVN PVVSYAVALS CQCALCRRST TDCGGPKDHP LTCDDPRFQD SSSSKAPPPS LPSPSRLPGP SDTPILPQHH HHHH.
