
Cataloguenumber
PRO-475
Synonyms
Mortalityfactor4-likeprotein2,MORF-relatedgeneXprotein,ProteinMSL3-2,Transcriptionfactor-likeproteinMRGX,MORF4L2,KIAA0026,MRGX,MORFL2.
Introduction
MORF4L2belongstothemortalityfactor(MORF)familyoftranscriptionalregulatorwhichisinvolvedincellgrowth,regulationandsenescence.MORF4L2localizestothenucleus,andithasaproteinkinaseCphosphorylationsiteaswellasatyrosinephosphorylationsite.MORF4L2interactswiththeRbtumorsuppressorthroughitshelix-loop-helixandleucinezipperregions.FurThermore,MORF4L2hashistonedeacetylaseactivityandcaneitherrepressorpromotetheactivityoftheB-Mybpromoterdependingonthetissue.
Description
MORF4L2producedinE.Coliisasingle,non-glycosylatedpolypeptidechaincontaining308aminoacids(1-288a.a.)andhavingamolecularmassof34.4kDa(MolecularweightonSDS-PAGEwillappearhigher).
MORF4L2isfusedtoa20aminoacidHis-tagatN-terminus&purifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
StABIlity
Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).
Avoidmultiplefreeze-thawcycles.
Purity
Aminoacidsequence
MGSSHHHHHHSSGLVPRGSHMSSRKQGSQPRGQQSAEEENFKKPTRSNMQRSKMRGASSGKKTAGPQQKNLEPALPGRWGGRSAENPPSGSVRKTRKNKQKTPGNGDGGSTSEAPQPPRKKRARADPTVESEEAFKNRMEVKVKIPEELKPWLVEDWDLVTRQKQLFQLPAKKNVDAILEEYANCKKSQGNVDNKEYAVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEILLAHPDAPMSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLGYLHDFLKYLAKNSASLFTASDYKVASAEYHRKAL.