Cataloguenumber
PRO-2466
Synonyms
KillerCellImmunoglobulinLikeReceptor,ThreeIgDomainsAndLongCytoplasmicTail2,KillerCellImmunoglobulin-LikeReceptor,ThreeDomains,LongCytoplasmicTail,2,P70NaturalKillerCellReceptorCloneCL-5,NaturalKiller-AssociatedTranscript4,CD158Antigen-LikeFamilyMemberK,MHCClassINKCellReceptor,P70NKReceptorCL-5,CD158K,NKAT-4,NKAT4,KillerCellImmunoglobulin-LikeReceptor3DL2,Killer-CellImmunoglobulin-LikeReceptor,P70KillerCellInhibitoryReceptor,KillerIgReceptor,KIRAntigen3DL2,CD158kAntigen,KIR-3DL2,NKAT4B,3DL2,P140.
Introduction
KillerCellImmunoglobulin-LikeReceptor,3DomainsLongCytoplasmicTail2(KIR3DL2)isatype1transmembraneproteinofthep70familyofkillercellIg-likereceptors.KIR3DL2isareceptoronNKcellsforHLA-AalleleswhichInhibitstheiractivityconsequentlypreventingcelllysis.
Description
KIR3DL2HumanRecombinantproducedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining561aminoacids(22-340a.a.)andhavingamolecularmassof62.2kDa(MolecularsizeonSDS-PAGEwillappearatapproximately70-100kDa).
KIR3DL2isexpressedwitha239aminoacidshIgG-HistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
KIR3DL2proteinsolution(0.5mg/ml)containsPhosphateBufferedSaline(pH7.4)and10%glycerol.
StABIlity
Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).
Avoidmultiplefreeze-thawcycles.
Purity
Greaterthan85.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
ADPLMGGQDKPFLSARPSTVVPRGGHVALQCHYRRGFNNFMLYKEDRSHVPIFHGRIFQESFIMGPVTPAHAGTYRCRGSRPHSLTGWSAPSNPLVIMVTGNHRKPSLLAHPGPLLKSGETVILQCWSDVMFEHFFLHREGISEDPSRLVGQIHDGVSKANFSIGPLMPVLAGTYRCYGSVPHSPYQLSAPSDPLDIVITGLYEKPSLSAQPGPTVQAGENVTLSCSSWSSYDIYHLSREGEAHERRLRAVPKVNRTFQADFPLGPATHGGTYRCFGSFRALPCVWSNSSDPLLVSVTGNPSSSWPSPTEPSSKSGICRHLHVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH.
