Cataloguenumber
PRO-2425
Synonyms
C-TypeLectinDomainContaining10A,C-TypeLectinDomainFamily10MemberA,C-Type(CalciumDependent,Carbohydrate-RecognitionDomain)Lectin,SuperfamilyMember14(Macrophage-Derived),MacrophageLectin2(CalciumDependent),CLECSF13,CLECSF14,HML,C-Type(CalciumDependent,Carbohydrate-RecognitionDomain)Lectin,SuperfamilyMember13(Macrophage-Derived),C-TypeLectinDomainFamily10,MemberA,C-TypeLectinSuperfamilyMember14,MacrophageLectin2,CD301Antigen,CD301,HML2,MGL.
Introduction
C-TypeLectinDomainFamily10,MemberA(CLEC10A)isapartoftheC-typelectinsuperfamily.CLEC10Aisexpressedinimmaturemyeloiddendriticcellsandalternativelyactivatedmacrophages.CLEC10AtakespartinregulatingadaptiveandinnateimmuneresponsesandalsobindsinacalciumdependentwaytoterminalgalactoseandN-acetylgalactosamine,linkedtoserineorthreonine.
Description
CLEC10AHumanRecombinantproducedinSf9Insectcellsisasingle,glycosylatedpolypeptidechaincontaining241aminoacids(61-292a.a.)andhavingamolecularmassof27.3kDa.(MolecularsizeonSDS-PAGEunderreducingconditions28-40kDa).
CLEC10Aisexpressedwitha9aminoacidsHistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
CLEC10Aproteinsolution(0.5mg/ml)containsPhosphateBufferedSaline(pH7.4).
StABIlity
Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).
Avoidmultiplefreeze-thawcycles.
Purity
Greaterthan90.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
ADPQNSKFQRDLVTLRTDFSNFTSNTVAEIQALTSQGSSLEETIASLKAEVEGFKQERQAVHSEMLLRVQQLVQDLKKLTCQVATLNNNGEEASTEGTCCPVNWVEHQDSCYWFSHSGMSWAEAEKYCQLKNAHLVVINSREEQNFVQKYLGSAYTWMGLSDPEGAWKWVDGTDYATGFQNWKPGQPDDWQGHGLGGGEDCAHFHPDGRWNDDVCQRPYHWVCEAGLGQTSQESHHHHHHH.