
Cataloguenumber
PRO-2465
Synonyms
CALU,Crocalbin,IEFSSP9302,FLJ90608,Calumenin.
Introduction
Calumeninisacalcium-bindingproteinlocatedintheendoplasmicreticulum(ER)andsarcoplasmicreticulum(SR)ofmammaliantissueswhichplaysaroleinERfunctionsasproteinfoldingandsorting.CalumeninbelongstoafamilyofmultipleEF-handproteins(CERC)thatincludereticulocalbin,ERC-55,andCab45andtheproductofthisgene.Calumeninbinds7calciumionshavinglowaffinityandtakespartinsuchERfunctionsasproteinfoldingandsorting.
Description
CalumeninHumanRecombinantproducedinE.coliisasinglepolypeptidechaincontaining297aminoacids(20-315)andhavingamolecularmassof35kDa.Calumeninispurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
TheCalumeninsolution(0.5mg/1ml)containsphosphatebufferedsaline(pH7.4)and10%glycerol.
StABIlity
Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).
Avoidmultiplefreeze-thawcycles.
Purity
Aminoacidsequence
MKPTEKKDRVHHEPQLSDKVHNDAQSFDYDHDAFLGAEEAKTFDQLTPEESKERLGKIVSKIDGDKDGFVTVDELKDWIKFAQKRWIYEDVERQWKGHDLNEDGLVSWEEYKNATYGYVLDDPDPDDGFNYKQMMVRDERRFKMADKDGDLIATKEEFTAFLHPEEYDYMKDIVVQETMEDIDKNADGFIDLEEYIGDMYSHDGNTDEPEWVKTEREQFVEFRDKNRDGKMDKEETKDWILPSDYDHAEAEARHLVYESDQNKDGKLTKEEIVDKYDLFVGSQATDFGEALVRHDEF.