
Cataloguenumber
PRO-242
Synonyms
AnteriorgrADIentprotein3homolog,AG-3,AG3,hAG-3,Breastcancermembraneprotein11,AGR3,BCMP11,UNQ642/PRO1272,HAG3,PDIA18.
Introduction
Anteriorgradientprotein3homologprecursor(AGR3)isasecretedcytoplasmicproteinthatisinvolvedinmetastasisinductionandp53tumorsuppressorinhibition.AGR3mayfunctionasmolecularMarkerandpotentialtherapeutictargetforhormone-responsivebreasttumors.
Description
AGR3producedinE.Coliisasingle,non-glycosylatedpolypeptidechaincontaining169aminoacids(22-166a.a)andhavingamolecularmassof19.5kDa.
AGR3isfusedtoa20aminoacidHis-tagatN-terminus&purifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
AGR3proteinsolution(1mg/ml)containing20mMTris-HClbuffer(pH8.0),20%glycerol,0.1MNaCland1mMDTT.
StABIlity
AGR3HumanRecombinantalthoughstableat4°Cfor1week,shouldbestoredbelow-18°C.
Pleasepreventfreezethawcycles.
Purity
Aminoacidsequence
MGSSHHHHHHSSGLVPRGSHMGSMIAIKKEKRPPQTLSRGWGDDITWVQTYEEGLFYAQKSKKPLMVIHHLEDCQYSQALKKVFAQNEEIQEMAQNKFIMLNLMHETTDKNLSPDGQYVPRIMFVDPSLTVRADIAGRYSNRLYTYEPRDLPLLIENMKKALRLIQSEL.