
Cataloguenumber
ENZ-101
Synonyms
Alpha-ketoglutarate-dependentdioxygenasealkBhomolog3,AlkylatedDNArepairproteinalkBhomolog3,DEPC-1,Prostatecancerantigen1,ALKBH3,ABH3,DEPC1,PCA1,FLJ43614,MGC118790,MGC118792,MGC118793.
Introduction
ALKBH3belongstotheALKBfamilyofproteinsandactsasadioxygenasewithapreferenceforRNAandsinglestrandedDNAsubstrates.ALKBH3proteinrepairs1-methyladenineand3-methylcytosinelesionsinalkylatedDNAandRNAanditsactivityisstimulatedbyascorbate.ALKBH3isexpressedinabroadarrayoftissuesandlocalizestothecytoplasmandthenucleus.
Description
ALKBH3HumanRecombinantfusedto39aminoacidHisTagatN-terminalproducedinE.Coliisasingle,non-glycosylated,polypeptidechaincontaining325aminoacids(1-286a.a.)andhavingamolecularmassof37.9kDa.
TheALKBH3ispurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
TheALKBH3solution1mg/mlcontains20mMTris-HClbuffer(pH8.0),10%glycerol,2mMDTTand0.1MNaCl.
StABIlity
Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).
Avoidmultiplefreeze-thawcycles.
Purity
Aminoacidsequence
MRGSHHHHHHGMASMTGGQQMGRDLYDDDDKDRWGSELDMEEKRRRARVQGAWAAPVKSQAIAQPATTAKSHLHQKPGQTWKNKEHHLSDREFVFKEPQQVVRRAPEPRVIDREGVYEISLSPTGVSRVCLYPGFVDVKEADWILEQLCQDVPWKQRTGIREDITYQQPRLTAWYGELPYTYSRITMEPNPHWHPVLRTLKNRIEENTGHTFNSLLCNLYRNEKDSVDWHSDDEPSLGRCPIIASLSFGATRTFEMRKKPPPEENGDYTYVERVKIPLDHGTLLIMEGATQADWQHRVPKEYHSREPRVNLTFRTVYPDPRGAPW.