Cataloguenumber
ENZ-104
Synonyms
Ubiquitin-conjugatingenzymeE2N,Bendless-likeubiquitin-conjugatingenzyme,Ubc13,UbiquitincarrierproteinN,Ubiquitin-proteinligaseN,UBE2N,BLU,MGC8489,UbcH-ben,MGC131857.
Introduction
UBE2NbelongstotheE2ubiquitin-conjugatingenzymefamily.UBE2NcatalyzestheATP-dependentsynthesisofnon-canonicalpolyubiquitinchains,aprocesswhichdoesn’tsetinmotionproteasomaldegradation.UBE2Nmediatesthetranscriptionofsometargetgenesandisbelievedtohavearoleincellcycleprogression;cellulardifferentiationandDNArepairmechanismswhichensurecellsurvivalafterDNAdamage.
Description
UBE2NproducedinE.Coliisasingle,non-glycosylatedpolypeptidechaincontaining172aminoacids(1-152a.a.)andhavingamolecularmassof19.3kDa.
UBE2Nisfusedtoa20aminoacidHis-tagatN-terminus&purifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
Aminoacidsequence
StABIlity
Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).
Avoidmultiplefreeze-thawcycles.