Cataloguenumber
ENZ-116
Synonyms
Ubiquitin-conjugatingenzymeE2D1,StimulatorofFetransport,SFT,UBC4/5homolog,UbcH5,UbiquitincarrierproteinD1,Ubiquitin-conjugatingenzymeE2(17)KB1,Ubiquitin-conjugatingenzymeE2-17kDa1,Ubiquitin-proteinligaseD1,UBE2D1,SFT,UBC5A,UBCH5A,E2(17)KB1.
Introduction
UBE2D1isamemberoftheubiquitin-conjugatingenzymefamily.Ubiquitinationinvolvesatleast3classesofenzymes:ubiquitin-activatingenzymes(E1s),ubiquitin-conjugatingenzymes(E2s)andubiquitin-proteinligases(E3s).UBE2D1isstronglyrelatedtoastimulatorofirontransport(SFT),andisup-regulatedinhereditaryhemochromatosis.Inaddition,UBE2D1functionsintheubiquitinationofthetumor-suppressorproteinp53andthehypoxia-inducIBLetranscriptionfactorHIF1alphabyinteractingwiththeE1ubiquitin-activatingenzymeandtheE3ubiquitin-proteinligases.
Description
UBE2D1producedinE.Coliisasingle,non-glycosylatedpolypeptidechaincontaining170aminoacids(1-147a.a.)andhavingamolecularmassof19kDa.
UBE2D1isfusedtoa23aminoacidHis-tagatN-terminus&purifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
Aminoacidsequence
MGSSHHHHHHSSGLVPRGSHMGSMALKRIQKELSDLQRDPPAHCSAGPVGDDLFHWQATIMGPPDSAYQGGVFFLTVHFPTDYPFKPPKIAFTTKIYHPNINSNGSICLDILRSQWSPALTVSKVLLSICSLLCDPNPDDPLVPDIAQIYKSDKEKYNRHAREWTQKYAM.
StABIlity
Pleasepreventfreezethawcycles.