Cataloguenumber
PKA-103
Synonyms
DiscoidinDomainReceptorTyrosineKinase1,CD167Antigen-LikeFamilyMemberA,Protein-TyrosineKinaseRTK-6,MammaryCarcinomaKinase10,Tyrosine-ProteinKinaseCAK,CellAdhesionKinase,TyrosineKinaseDDR,EC2.7.10.1,EDDR1,NTRK4,PTK3A,HGK2,RTK6,TRKE,CAK,NEP,NeurotrophicTyrosineKinase,Receptor,Type4,DiscoidinDomainReceptorFamily,Member1,EpithelialDiscoidinDomainReceptor1,DiscoidinReceptorTyrosineKinase,PTK3AProteinTyrosineKinase3A,NeuroepithelialTyrosineKinase,Protein-TyrosineKinase3A,CD167aAntigen,EC2.7.10,MCK-10,CD167,MCK10,TRKE,PTK3,DDR.
Introduction
DiscoidinDomainReceptorTyrosineKinase1(DDR1)isatransmembraneglycoproteinwhichisapartofthediscoidin-likedomaincontainingsubfamilyofreceptortyrosinekinases.DDR1functionsascellsurfacereceptorforfibrillarcollagenandregulatescellattachmenttotheextracellularmatrix,remodelingoftheextracellularmatrix,cellmigration,differentiation,survivalandcellproliferation.DDR1isexpressedinepithelialcells,mainlyinthekidney,lung,gastrointestinaltract,andbrainandissignificantlyoverexpressedinseveralhumantumors.
Description
DDR1HumanRecombinantproducedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining636aminoacids(21-417a.a.)andhavingamolecularmassof71.0kDa(MolecularsizeonSDS-PAGEwillappearatapproximately70-100kDa).
DDR1isexpressedwitha239aminoacidhIgG-HistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
DDR1proteinsolution(0.5mg/ml)containsPhosphateBufferedSaline(pH7.4)and10%glycerol.
StABIlity
Purity
Greaterthan90.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
DMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAARHSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRLRYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDDFRKSQELRYVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGGVECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFSEISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTALEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH.

