Cataloguenumber
ENZ-115
Synonyms
PutativeATP-dependentClpproteaseproteolyticsubunitmitochondrial,EndopeptidaseClp,CLPP.
Introduction
ATP-dependentClpproteaseproteolyticsubunit(CLPP)isamemberofthepeptidasefamilyS14.CLPPcleavespeptidesinavarietyofproteinsinamannerwhichrequiresATPhydrolysis.CLPPbeingthecatalyticcoreoftheClpproteolyticcomplexiscommonlyinvolvedinmanycellularprocessesviatheregulationofintracellularproteinquality.CLPPisresponsIBLeforasomewhatgeneralandcentralhousekeepingfunctionratherthanforthedegradationofspecificsubstrates.
Description
CLPPproducedinE.Coliisasingle,non-glycosylatedpolypeptidechaincontaining222aminoacids(57-277a.a.)andhavingamolecularmassof24.2kDa.
CLPPispurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
Aminoacidsequence
MPLIPIVVEQTGRGERAYDIYSRLLRERIVCVMGPIDDSVASLVIAQLLFLQSESNKKPIHMYINSPGGVVTAGLAIYDTMQYILNPICTWCVGQAASMGSLLLAAGTPGMRHSLPNSRIMIHQPSGGARGQATDIAIQAEEIMKLKKQLYNIYAKHTKQSLQVIESAMERDRYMSPMEAQEFGILDKVLVHPPQDGEDEPTLVQKEPVEAAPAAEPVPAST.
StABIlity
Storeat4°Cifentirevialwillbeusedwithin2-4weeks.Store,frozenat-20°Cforlongerperiodsoftime.
Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).
Avoidmultiplefreeze-thawcycles.

