Cataloguenumber
ENZ-1047
Synonyms
KallikreinRelatedPeptidase15,ACOProtease,Kallikrein-LikeSerineProtease,Kallikrein15,Kallikrein-15,Prostinogen,EC3.4.21.4,EC3.4.21.-, EC3.4.21,HSRNASPH,ACO.
Introduction
Kallikrein-15(KLK15)isoneofthe15kallikreinsubfamilymemberslocatedinaclusteronchromosome19.KLK15containsnumerouspolyadenylationsitesandalternativesplicingresultsinmultipletranscriptvariantsencodingdifferentisoforms.KLK15isoverexpressedinprostatecancerandthereforeusesasadiagnosticorprognosticMarkerforprostatecancer.
Description
KLK15HumanRecombinantproducedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining249aminoacids(17-256a.a.)andhavingamolecularmassof27.4kDa(MolecularsizeonSDS-PAGEwillappearatapproximately28-40kDa).
KLK15isexpressedwitha6aminoacidsHistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
KLK15proteinsolution(0.25mg/ml)containsPhosphateBufferedSaline(pH7.4)and10%glycerol.
StABIlity
Purity
Greaterthan80.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
ADPQDGDKLLEGDECAPHSQPWQVALYERGRFNCGASLISPHWVLSAAHCQSRFMRVRLGEHNLRKRDGPEQLRTTSRVIPHPRYEARSHRNDIMLLRLVQPARLNPQVRPAVLPTRCPHPGEACVVSGWGLVSHNEPGTAGSPRSQVSLPDTLHCANISIISDTSCDKSYPGRLTNTMVCAGAEGRGAESCEGDSGGPLVCGGILQGIVSWGDVPCDNTTKPGVYTKVCHYLEWIRETMKRNHHHHHH.

