Cataloguenumber
ENZ-1039
Synonyms
Peptidyl-prolylcis-transisomeraseB,PPIaseB,CYP-S1,CyclophilinB,RotamaseB,S-cyclophilin,SCYLP.
Introduction
CyclophilinB(alsoknownasPPIB,peptidylpropylisomeraseB)isacyclosporine-bindingproteinandismainlylocatedwithintheendoplasmicreticulum.ItisassociatedwiththesecretorypathwayandreleasedinBIOLOGicalfluids.ThisproteincanbindtocellsderivedfromT-andB-lymphocytes,andmayregulatecyclosporineA-mediatedimmunosuppression.
Description
CyclophilinBMouseRecombinantproducedinE.Coliisasingle,non-glycosylatedpolypeptidechaincontaining207aminoacids(34-216a.a)andhavingamolecularmassof22.7kDa.
CyclophilinBisfusedtoa24aminoacidHis-tagatN-terminus&purifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
CyclophilinBproteinsolution(1mg/ml)containingPhosphateBufferedSaline(pH7.4)and10%glycerol.
StABIlity
Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).
Avoidmultiplefreeze-thawcycles.
Purity
Aminoacidsequence
MGSSHHHHHHSSGLVPRGSHMGSMNDKKKGPKVTVKVYFDLQIGDESVGRVVFGLFGKTVPKTVDNFVALATGEKGFGYKNSKFHRVIKDFMIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTSWLDGKHVVFGKVLEGMDVVRKVESTKTDS
RDKPLKDVIIVDSGKIEVEKPFAIAKE.
BiologicalActivity
Specificactivityis>1,000nmol/min/mg,andisdefinedastheamountofenzymethatcleaves1nmoleofsuc-AAFP-PNAperminuteat37CinTris–HClpH8.0usingchymotrypsin.
Usage
Prospec"sproductsarefurnishedforLABORATORYRESEARCHUSEONLY.Theymaynotbeusedasdrugs,agriculturalorpesticidalproducts,foodadditivesorhouseholdchemicals.

