Cataloguenumber
PRO-2419
Synonyms
CD160Molecule,CD160Antigen,NaturalKillerCellReceptorBY55,BY55,NaturalKillerCellReceptor,ImmunoglobulinSuperfamilyMember,CD160TransmembraneIsoform,CD160-DeltaIg,NK28,NK1,CD160.
Introduction
CD160antigen(CD160)isahumannaturalkiller(NK)-cell-activatingreceptorwhichisalsoexpressedonT-cellsubsets.CD160isatumor-specificantigenknowntomediatecellularactivationsignalsinCLL,andisanoveltargetfortherapeuticmanipulationandmonitoringofminimalresidualdisease.CD160wasidentifiedasaTcellcoinhibitorymoleculewhichinteractswiththeherpesvirusentrymediator(HVEM)onantigen-presentingcellstodeliverapotentinhibitorysignaltoCD4(+)Tcells.CD160expressionisstronglyassociatedwithperipheralbloodNKcellsandCD8Tlymphocyteswithcytolyticeffectoractivity.CD160isexpressedonallintestinalintraepitheliallymphocytes.CD160hasabroadspecificityforbindingtobothclassicalandnonclassicalMHCclassImolecules.
Description
CD160HumanRecombinantproducedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining142aminoacids(27-159a.a.)andhavingamolecularmassof15.9kDa(MolecularsizeonSDS-PAGEwillappearatapproximately18-28kDa).CD160isexpressedwitha6aminoacidsHistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
Sf9,Baculoviruscells.
PhysicalAppearance
Formulation
CD160proteinsolution(0.25mg/ml)containsPhosphateBufferedSaline(pH7.4)and10%glycerol.
StABIlity
Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).
Avoidmultiplefreeze-thawcycles.
Purity
Greaterthan90.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
ADLINITSSASQEGTRLNLICTVWHKKEEAEGFVVFLCKDRSGDCSPETSLKQLRLKRDPGIDGVGEISSQLMFTISQVTPLHSGTYQCCARSQKSGIRLQGHFFSILFTETGNYTVTGLKQRQHLEFSHNEGTLSHHHHHH.