Cataloguenumber
PRO-2468
Synonyms
CD79aMolecule,Membrane-BoundImmunoglobulin-AssociatedProtein,CD79AAntigen(Immunoglobulin-AssociatedAlpha),CD79aMolecule,Immunoglobulin-AssociatedAlpha,SurfaceIgM-AssociatedProtein,MB-1MembraneGlycoprotein,Ig-Alpha,IGA,B-CellAntigenReceptorComplex-AssociatedProteinAlphaChain,CD79aAntigen,MB-1,MB1.
Introduction
CD79Aisasignal-transducingpartoftheB-cellreceptorwhichplaysvariousrolesinBcelldevelopmentandfunction.CD79AisalsoneededforBCRsurfaceexpressionandforefficientdifferentiationofpro-Bandpre-B-cells.CD79Aplaysanimportantroleinthetumorpromotingeffectsofmyeloidcells,andisanoveltargetforcancertherapy.
Description
CD79AHumanRecombinantproducedinSf9Insectcellsisasingle,glycosylatedpolypeptidechaincontaining119aminoacids(33-143a.a.)andhavingamolecularmassof13.6kDa(MolecularsizeonSDS-PAGEwillappearatapproximately18-28kDa).
CD79Aisexpressedwitha8aminoacidHistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
Sf9,Insectcells.
Purity
Greaterthan95.0%asdeterminedbySDS-PAGE.
Formulation
CD79Aproteinsolution(1mg/ml)containsPhosphateBufferedSaline(pH7.4)and10%glycerol.
StABIlity
Storeat4°Cifentirevialwillbeusedwithin2-4weeks.
Store,frozenat-20°Cforlongerperiodsoftime.
Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).
Avoidmultiplefreeze-thawcycles.
Aminoacidsequence
LWMHKVPASLMVSLGEDAHFQCPHNSSNNANVTWWRVLHGNYTWPPEFLGPGEDPNGTLIIQNVNKSHGGIYVCRVQEGNESYQQSCGTYLRVRQPPPRPFLDMGEGTKNRLEHHHHHH.