
Cataloguenumber
ANT-713
Synonyms
Calnexin,MajorhistocompatibilitycomplexclassIantigen-bindingproteinp88,p90,IP90,CANX,CNX,FLJ26570.
Type
Introduction
Calnexin(CANX)belongstothecalnexinfamilyofmolecularchaperones.Calnexinisacalcium-binding,ER-associatedproteinthatinteractsbrieflywithnewlysynthesizedN-linkedglycoproteins,facilitatingproteinfoldingandassembly.CalnexinmayalsohaveakeyroleinthequalitycontrolofproteinfoldingbyretainingincorrectlyfoldedproteinsubunitswithintheERfordegradation.Calnexingrantslong-termprotectionofwild-typeShakerproteinfromER-associateddegradation.PolypeptidesubstraterecognitionbyCalnexinrequiresspecificconformationsoftheCalnexinprotein.Calnexindwindleswithagingandmightcontributetoacytoprotectioninanarrayofhumanage-relateddiseases.
Clone
PAT18B9AT.
PhysicalAppearance
Immunogen
Anti-humanCANXmAb,isderivedfromhybridizationofmouseF0myelomacellswithspleencellsfromBALB/cmiceimmunizedwitharecombinanthumanCANXprotein21-481aminoacidspurifiedfromE.coli.
IgSubclass
MouseIgG1heavychainandklightchain.
PurificationMethod
CANXantibodywaspurifiedfrommouseasciticfluidsbyprotein-Aaffinitychromatography.
Formulation
1mg/mlcontainingPBS,pH-7.4,10%Glyceroland0.02%SodiumAzide.
StorageProcedures
StABIlity/ShelfLife
Applications
CANXantibodyhasbeentestedbyELISAandWesternblotanalysistoassurespecificityandreactivity.Sinceapplicationvaries,however,eachinvestigationshouldbetitratedbythereagenttoobtainoptimalresults.
SafetyDataSheet
SDS