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Prospec/CD11b Antibody, FITC/CD11b, Mouse Anti-Human, FITC/500µg/ANT-276-500µg

Cataloguenumber
ANT-276
Synonyms
Type
Introduction
Integrinsareheterodimericintegralmembraneproteinscomposedofanalphachainandabetachain.ThisI-domaincontainingalphaintegrincombineswiththebeta2chain(ITGB2)toformaleukocyte-specificintegrinreferredtoasmacrophagereceptor1("Mac-1"),orinactivated-C3b(iC3b)receptor3("CR3").ThealphaMbeta2integrinisimportantintheadherenceofneutrophilsandmonocytestostimulatedendothelium,andalsointhephagocytosisofcomplementcoatedparticles.Integrinalpha-m/beta-2isimplicatedinvariousadhesiveinteractionsofmonocytes,macrophagesandgranulocytesaswellasinmediatingtheuptakeofcomplement-coatedparticles.CD-11bisidenticalwithcr-3,thereceptorfortheic3bfragmentofthethirdcomplementcomponent.CD-11bprobablyrecognizesther-g-dpeptideinc3b.Integrinalpha-m/beta-2isalsoareceptorforfibrinogen,factorxandicam1.itrecognizesp1andp2peptidesoffibrinogengammachain.
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