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Prospec/FAS Antibody (CD95)/FAS Antibody (CD95), Mouse Anti Human/100µg/ANT-735-100µg
Cataloguenumber
ANT-735
Synonyms
FASLGreceptor,Apoptosis-mediatingsurfaceantigenFAS,Apo-1antigen,CD95,Tumornecrosisfactorreceptorsuperfamilymember6TNR6,APT1,FAS1,TNFRSF6.
Type
MouseAntiHumanMonoclonal.
Introduction
TheFasreceptor(CD95)mediatesapoptoticsignalingbyFas-ligandexpressedonthesurfaceofothercells.TheFas-FasLinteractionplaysanimportantroleintheimmunesystemandlackofthissystemleadstoautoimmunity,indicatingthatFas-mediatedapoptosisremovesself-reactivelymphocytes.Fassignalingisalsoinvolvedinimmunesurveillancetoremovetransformedcellsandvirusinfectedcells.BindingofFAStooligimerizedFasLonanothercellactivatesapoptoticsignalingthroughacytoplasmicdomaintermedthedeathdomainthatinteractswithsignalingadaptorsincludingFAF,FADDandDAXtoactivatethecaspaseproteolyticcascade.Caspase-8andcaspase-10arefirstactivated,tothencleaveandactivatedownstreamcaspases,andavarietyofcellularsubstratesthatleadtocelldeath.Caspasescleavenuclearlamins,causingthenucleustobreakdownandloseitsnormalstructureandanothercaspasesubstrateisDFF,inducingcleavageanddegradationofthegenome.Othercaspasesubstratesareinvolvedincytoskeletalstructure,cellcycleregulationandsignalingpathways.ActivationofJNKkinase,activationofJun,andproductionofceramidemayalsoplayrolesinFas-mediatedapoptosis.Activationoffas-mediatedapoptosisisopposedbyI-FLICEandFAP.Virusesandtumorsmayescapeimmunesurveillanceinpartthroughsuppressionoffas-mediatedapoptosisusingsimilarmechanisms.
Clone
pprro-160
Immunogen
RecombinantHumanFAS.
IgSubclass
MouseIgG2a
PurificationMethod
Protein-Acolumn.
Formulation
1XPBSpH7.4,0.5%Saccharose,0.2%gelatinand0.1%NaN3.
PhysicalAppearance
Sterilefilteredcolorlesssolution.
StorageProcedures
Forperiodsupto1monthstoreat4°C,forlongerperiods,storeat-20°C.
Preventfreezethawcycles.
Applications
FASAntibodycanbeusedinFlowcytometry.
SafetyDataSheet
SDS
