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Prospec/ANGPTL3 (PAT23D8AT) Antibody/Mouse Anti Human Angiopoietin Like Protein 3 Clone PAT23D8AT/20µg/ANT-709-20µg

Cataloguenumber
ANT-709
Synonyms
AngiopoietinLike3,Angiopoietin5,ANGPT5,ANG-5,Angiopoietin-RelatedProtein3,Angiopoietin-LikeProtein3,Angiopoietin-Like3,Angiopoietin-5,FHBL2,ANL3.
Type
Introduction
ANGPTL3andANGPTL4areangiopoietin-likeproteinssecretedandexpressedmainlybytheliver,theirrolebeingtheregulationoftriglyceridemetabolismbyinhibitingthelipolysisoftriglyceride-richlipoproteins.Duringdifferentnutritionalstates(feeding/fasting)thelevelsofthecirculatingtriglyceridesareregulatedbyAngptl3andAngptl4throughdifferentialinhibitionofLipoproteinlipase(LPL)asshownbytheexperimentaldata.ThemolecularstructureofANGPTL3issimilartothatoftheangiopoietins(vascularendothelialgrowthfactors).DeletionmutantsofhumanAngiopoietin5wereusedinordertodemonstratethattheN-terminaldomain(fragment17-207)andnottheC-terminalfibrinogen-likedomain(fragment207-460)increasedtheplasmatriglyceridelevelsinmice.
Clone
PAT23D8AT.
PhysicalAppearance
Immunogen
Anti-humanANGPTL3mAb,isderivedfromhybridizationofmouseF0myelomacellswithspleencellsfromBALB/cmiceimmunizedwitharecombinanthumanANGPTL3protein243-460aminoacidspurifiedfromE.coli.
IgSubclass
MouseIgG2aheavychainandκlightchain.
PurificationMethod
ANGPTL3antibodywaspurifiedbyprotein-Aaffinitychromatography.
Formulation
1mg/mlcontainingPBS,pH-7.4,10%Glyceroland0.02%SodiumAzide.
StorageProcedures
StABIlity/ShelfLife
Applications
ANGPTL3antibodyhasbeentestedbyELISA,WesternblotanalysisandICC/IFtoassurespecificityandreactivity.Sinceapplicationvaries,however,eachinvestigationshouldbetitratedbythereagenttoobtainoptimalresults.
SafetyDataSheet
SDS