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Prospec/TSPAN7 Human/Tetraspanin 7 Human Recombinant/2µg/PRO-2414-2µg

Cataloguenumber
PRO-2414
Synonyms
Tspan-7,CellsurfaceglycoproteinA15,MembranecomponentchromosomeXsurfaceMarker1,T-cellacutelymphoblasticleukemia-associatedantigen1,TALLA-1,Transmembrane4superfamilymember2,CD231,A15,DXS1692E,MXS1,TM4SF2.
Introduction
Tetraspanin7,alsoknownasTSPAN7,ispartofthetransmembrane4superfamily,whichisalsofamiliarasthetetraspaninfamily.Mostoftheseproteinsmediatesignaltransductioneventswhichplayaroleintheregulationofcelldevelopment,activation,growthaswellasmotility.FurThermore,TSPAN7isassociatedwithX-linkedmentalretardationinadditiontoneuropsychiatricdiseasessuchasHuntington"schorea,fragileXsyndromeandmyotonicdystrophy.Lately,TSPAN7hasbeenacknowledgedasakeyimmunesystemtargetintype1diabetes.
Description
TSPAN7HumanRecombinantproducedinSf9Insectcellsisasingle,glycosylatedpolypeptidechaincontaining110aminoacids(113-213a.a.)andhavingamolecularmassof12.6kDa.(MolecularsizeonSDS-PAGEunderreducingconditions13.5-18kDa).TSPAN7isexpressedwitha6aminoacidsHistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
TSPAN7proteinsolution(0.5mg/ml)containsPhosphateBufferedSaline(pH7.4)and10%glycerol.
StABIlity
Purity
Greaterthan90.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
ADPRHEIKDTFLRTYTDAMQTYNGNDERSRAVDHVQRSLSCCGVQNYTNWSTSPYFLEHGIPPSCCMNETDCNPQDLHNLTVAATKVNQKGCYDLVTSFMETNMHHHHHH.
SafetyDataSheet
SDS