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Other_recombinant_protein >
Prospec/PVR Human/Poliovirus Receptor Human Recombinant/1µg/PRO-2463-1µg
Cataloguenumber
PRO-2463
Synonyms
Poliovirusreceptor,Nectin-likeprotein5,NECL-5,CD155,PVR,PVS.
Introduction
Poliovirusreceptor,alsoknownasPVR,isaTypeItransmembraneglycoproteinwhichbelongstotheimmunoglobulinsuperfamily.PVRcatalyzesabigstructuralmodificationintheviruswhichexposesmembrane-bindingproteinchains.PVRregulateshelperTcelldifferentiationaswellasallergicdiseases.PVRisexpressedinmanykindsofhumancellsandhasvariousfunctions.PVRispotentiallyfunctionalasabioMarkerforcancerdevelopmentaswellasprogression.PVRtakesavitalpartthroughbothimmunological&non-immunologicalmechanismsinpancreaticcancer.
Description
PVRHumanRecombinantproducedinSf9Insectcellsisasingle,glycosylatedpolypeptidechaincontaining331aminoacids(21-343a.a.)andhavingamolecularmassof36.1kDa(MolecularsizeonSDS-PAGEwillappearatapproximately40-57kDa).PVRisexpressedwithan8aminoacidsHistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
PVRproteinsolution(1mg/ml)containsPhosphateBufferedSaline(pH7.4)and10%glycerol.
StABIlity
Purity
Greaterthan90.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
WPPPGTGDVVVQAPTQVPGFLGDSVTLPCYLQVPNMEVTHVSQLTWARHGESGSMAVFHQTQGPSYSESKRLEFVAARLGAELRNASLRMFGLRVEDEGNYTCLFVTFPQGSRSVDIWLRVLAKPQNTAEVQKVQLTGEPVPMARCVSTGGRPPAQITWHSDLGGMPNTSQVPGFLSGTVTVTSLWILVPSSQVDGKNVTCKVEHESFEKPQLLTVNLTVYYPPEVSISGYDNNWYLGQNEATLTCDARSNPEPTGYNWSTTMGPLPPFAVAQGAQLLIRPVDKPINTTLICNVTNALGARQAELTVQVKEGPPSEHSGMSRNLEHHHHHH
SafetyDataSheet
SDS

