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Prospec/PEA15 Human/Phosphoprotein Enriched in Astrocytes 15 Human Recombinant/10µg/PRO-729-10µg

Cataloguenumber
PRO-729
Synonyms
Introduction
PEA15(Phospho-enrichedproteininastrocytes15kDa)isadeatheffectordomain(DED)-containingproteinmainlyexpressedinthecentralnervoussystem,principallyinastrocytes.PEA15isimplicatedintheregulationofvariouscellularprocessesincludingapoptosis,proliferation,glucosetransport,adhesionandmigration.IncreasedPEA15levelshaveanaffecttumOrigenesisandcancerprogression,thereforeitisoverexpressedinbreastcancersandgliomasaswellasintype2diabetes.PEA15blocksRas-mediatedinhibitionofintegrinactivationandmodulatestheERKMAPkinasecascade.PEA15alsoinhibitsRPS6KA3activitiesbyholdingitinthecytoplasm.Inaddition,PEA15inhibitsbothTNFRSF6andTNFRSF1AmediatedCASP8activityandapoptosis.PEA15isubiquitouslyexpressed.PEA15ismostabundantintissuessuchastheheart,brain,muscleandADIposetissuewhichuseglucoseasanenergysource.LowerPEA15expressionisinglucose-producingtissues.HigherlevelsofPEA15expressionarefoundintissuesfromindividualswithtype2diabetesthanincontrols.PEA15expressionisasignificantprognosticMarkerinovariancancer.
Description
Source
PhysicalAppearance
Formulation
StABIlity
Aminoacidsequence
SafetyDataSheet
SDS