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Prospec/OSCAR Human, Sf9/Osteoclast Associated, Immunoglobulin-Like Receptor Human Recombinant, Sf9/2µg/PRO-2546-2µg

Cataloguenumber
PRO-2546
Synonyms
OSCAR,PIgR-3,PIGR3,hOSCAR,PIgR-3,Poly-IgReceptor3.
Introduction
Osteoclast-associatedimmunoglobulin-likereceptorisoform6orOSCAR,isareceptorforsurfactantproteinDthatcanbefoundonhumanmyeloidcells.OSCARispartoftheTNF-αreleasefromhumanCCR2+inflammatorymonocytesprocess.Theproteinisinvolvedinantigenpresentationandactivationofdendriticcells.PreosteoclastsormatureosteoclastsexpresstheOSCARprotein.PatientsthatsufferfromRA(rheumatoidarthritis)hasupregulationsonmonocyteswhichpresentincreasedproosteoclastogenicpotential.
Description
OSCARproducedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechain(19-282a.a.)andfusedtoa6aaHisTagatC-terminuscontainingatotalof270aminoacidsandhavingamolecularmassof29.2kDa.OSCARshowsmultiplebandsbetween40-57kDaonSDS-PAGE,reducingconditionsandpurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
OSCARproteinsolution(0.25mg/ml)containsPhosphateBufferedSaline(pH7.4)&10%glycerol.
StABIlity
Purity
Greaterthan90.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
DITPSVPPASYHPKPWLGAQPATVVTPGVNVTLRCRAPQPAWRFGLFKPGEIAPLLFRDVSSELAEFFLEEVTPAQGGSYRCCYRRPDWGPGVWSQPSDVLELLVTEELPRPSLVALPGPVVGPGANVSLRCAGRLRNMSFVLYREGVAAPLQYRHSAQPWADFTLLGARAPGTYSCYYHTPSAPYVLSQRSEVLVISWEGEGPEARPASSAPGMQAPGPPPSDPGAQAPSLSSFRPRGLVLQPLLPQTQDSWDPAPPPSDPGVHHHHHH.
SafetyDataSheet
SDS