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Other_recombinant_protein >
Prospec/NFATC2 Human/Nuclear Factor Of Activated T Cells 2 Human Recombinant/1µg/PRO-2535-1µg

Cataloguenumber
PRO-2535
Synonyms
NuclearFactorOfActivatedTCells2,NuclearFactorOfActivatedT-Cells,Cytoplasmic,Calcineurin-Dependent2,NuclearFactorOfActivatedT-Cells2,NFATPre-ExistingSubunit,NF-ATc2,NFAT1,NFATP,NuclearFactorOfActivatedT-Cells,PreexistingComponent,NuclearFactorOfActivatedT-Cells,Cytoplasmic2,NFATTranscriptionComplex,PreexistingComponent,PreexistingNuclearFactorOfActivatedT-Cells2,TCellTranscriptionFactorNFAT1,T-CellTranscriptionFactorNFAT1,NF-ATp,NFATc2.
Introduction
NFATC2,alsoknownasnuclearfactorofactivatedT-cells2,belongstothenuclearfactorofactivatedTcellsfamily.NFATC2takesasignificantpartinthecourseofThelpercelldifferentiation,activation,andeffectorfunction.EventhoughKOofanindividualNFATisoforminTcellsdirectstoratherminoreffects,TcellslackingforNFATC1and2totallyfailtoproduceThelpercelleffectorcytokines,forinstancetheinterleukinsIL-4andIL-2.Moreover,NFATC2ishighlyphosphorylatedandkeptinthecytoplasm.NextTcellreceptorstimulation,dephosphorylationviacalcium-activatedcalcineurininducesaconformationalmodificationofNFATC2whichrevealsafewnuclearlocalizationsequences.
Description
NFATC2producedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining290aminoacids(396-678a.a.)andhavingamolecularmassof33.1kDa.(MolecularsizeonSDS-PAGEwillappearatapproximately28-40kDa).NFATC2isexpressedwitha7aminoacidHistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
NFATC2proteinsolution(0.25mg/ml)containsPhosphateBufferedSaline(pH7.4)40%glyceroland1mMDTT.
StABIlity
Purity
Greaterthan90.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
MPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVHHHHHH
SafetyDataSheet
SDS