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Other_recombinant_protein >
Prospec/NDE1 Human/nudE Nuclear Distribution Gene E Homolog 1 Human Recombinant/20µg/PRO-204-20µg

Cataloguenumber
PRO-204
Synonyms
NucleardistributionproteinnudEhomolog1,NudE,NDE1,NUDE,LIS4,NUDE1,HOM-TES-87.
Introduction
NDE1isacytoplasmicproteinwhichisamemberofthenudEproteinfamily.Phosphorylatedduringmitosis,NDE1iscriticalfortheformationandfunctionofthemitoticspindleinMphaseandfunctionstoregulatetheDynein-mediatedtransportofkinetochoreproteins,aswellascentrosomeduplicationduringinterphase.NDE1isbelievedtointeractwithNDEL1,LIS1andDyneinIC1/2,cytosolicinasignalingpathwaywhichregulatestheformationofneuronsandisfundamentaltothedevelopmentofthecerebralcortex.
Description
NDE1producedinE.Coliisasingle,non-glycosylatedpolypeptidechaincontaining355aminoacids(1-335a.a.)andhavingamolecularmassof39.9kDa(MolecularweightonSDS-PAGEwillappearhigher).NDE1isfusedtoa20aminoacidHis-tagatN-terminus&purifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
StABIlity
NDE1HumanRecombinantalthoughstableat4°Cfor1week,shouldbestoredbelow-18°C.Pleasepreventfreezethawcycles.
Purity
Aminoacidsequence
MGSSHHHHHHSSGLVPRGSHMEDSGKTFSSEEEEANYWKDLAMTYKQRAENTQEELREFQEGSREYEAELETQLQQIETRNRDLLSENNRLRMELETIKEKFEVQHSEGYRQISALEDDLAQTKAIKDQLQKYIRELEQANDDLERAKRATIMSLEDFEQRLNQAIERNAFLESELDEKENLLESVQRLKDEARDLRQELAVQQKQEKPRTPMPSSVEAERTDTAVQATGSVPSTPIAHRGPSSSLNTPGSFRRGLDDSTGGTPLTPAARISALNIVGDLLRKVGALESKLASCRNLVYDQSPNRTGGPASGRSSKNRDGGERRPSSTSVPLGDKGLDTSCRWLSKSTTRSSSSC.
SafetyDataSheet
SDS