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Other_recombinant_protein >
Prospec/IFIH1 Human/Interferon Induced With Helicase C Domain 1 Human Recombinant/10µg/PRO-1505-10µg

Cataloguenumber
PRO-1505
Synonyms
Introduction
IFIH1isaDEADboxproteinwhichisupregulatedinresponsetotreatmentwithbeta-interferonandaproteinkinaseC-activatingcompound,mezerein.IrreversIBLereprogrammingofmelanomascanbeattainedbytherapywithboththeseagents;treatmentwitheitheragentaloneonlyachievesreversibledifferentiation.DEADboxproteinsareimplicatedinseveralcellularprocessesinvolvingalterationofRNAsecondarystructuresuchastranslationinitiation,nuclearandmitochondrialsplicing,andribosomeandspliceosomeassembly.
Description
IFIH1HumanRecombinantproducedinSF9isaglycosylated,polypeptidechainhavingacalculatedmolecularmassof152,000Dalton.IFIH1isexpressedwitha-10xHistagatN-terminusandpurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
IFIH1issuppliedin20mMHEPESbufferpH-7.9,550mMNaCland6MUrea.
StABIlity
Purity
Greaterthan93.0%asdeterminedbySDS-PAGE.
SafetyDataSheet
SDS