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Other_recombinant_protein >
Prospec/FCMR Human/Fc Fragment Of IgM Receptor Human Recombinant/10µg/PRO-2579-10µg

Cataloguenumber
PRO-2579
Synonyms
Fasapoptoticinhibitorymolecule3,IgMFcfragmentreceptor,RegulatorofFas-inducedapoptosisToso,FAIM3,TOSO.
Introduction
Fasapoptoticinhibitorymolecule3orFCMRtakespartinprocessesoccurringwithintheimmunesystem.TheFCMRisprotectingcellsfromapoptosisthatisinducedbyFADD,FASandTNFalphaproteins,withoutoverexpressinginhibitorsofapoptosissuchasBCLXLorBCL2.FCMRactivatesaninhibitorypathwaythatinhibitsCASP8activation,insteadofblockingapoptoticsignalsdownstream.
Description
FCMRHumanRecombinantproducedinE.Coliisasingle,non-glycosylated,polypeptidechain(a.a18-250)containing243aminoacidsincludinga10a.aN-terminalHistag.Thetotalmolecularmassis27.2kDa(calculated).
Source
PhysicalAppearance
Formulation
FCMRfiltered(0.4µm)andlyophilizedfrom0.5mg/mlin50mMacetatebuffer,pH4.
Solubility
Itisrecommendedtoadd0.1Macetatebuffer,pH4toprepareaworkingstocksolutionofapproximately0.5mg/mlandletthelyophilizedpelletdissolvecompletely.Inhigherconcentrationsthesolubilityofthisantigenislimited.
StABIlity
Purity
Greaterthan95.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
MKHHHHHHASRILPEVKVEGELGGSVTIKCPLPEMHVRIYLCREMAGSGTCGTVVSTTNFIKAEYKGRVTLKQYPRKNLFLVEVTQLTESDSGVYACGAGMNTDRGKTQKVTLNVHSEYEPSWEEQPMPETPKWFHLPYLFQMPAYASSSKFVTRVTTPAQRGKVPPVHHSSPTTQITHRPRVSRASSVAGDKPRTFLPSTTASKISALEGLLKPQTPSYNHHTRLHRQRALDYGSQSGREGQ.
SafetyDataSheet
SDS
Usage
Prospec"sproductsarefurnishedforLABORATORYRESEARCHUSEONLY.Theymaynotbeusedasdrugs,agriculturalorpesticidalproducts,foodadditivesorhouseholdchemicals.