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Other_recombinant_protein >
Prospec/FCAR Human/Fc Fragment Of IgA Receptor Human Recombinant/1µg/PRO-2471-1µg

Cataloguenumber
PRO-2471
Synonyms
FcFragmentOfIgAReceptor,FcFragmentOfIgA,ReceptorFor,CD89,ImmunoglobulinAlphaFcReceptor,FcAlphaReceptor,FCARVariant14,IgAFcReceptor,CD89Antigen,CTB-61M7.2,FcalphaRI,ImmunoglobulinalphaFcreceptor,IgAFcreceptor.
Introduction
FcFragmentOfIgAReceptor,alsoknownasFCAR,ispartofthemultichainimmunerecognitionreceptorfamilywhichisthemostabundantimmunoglobulininmucosalareashoweveritisonlythesecondmostcommonantibodyisotypeinserum.FCARparticipatesinbothpro-andanti-inflammatoryresponsesdependingonthestateofIgAbound.FCARisalsoavitalFcreceptorforneutrophilkillingoftumorcells.OnceFCARexpressingneutrophilsinteractwithIgA-opsonizedtumorcells,theneutrophilsnotonlyshowantibody-dependentcell-mediatedcytotoxicity,butalsoreleasethecytokinesTNF-αandIL-1βwhichcauseincreasedneutrophilmigrationtothesite.
Description
FCARproducedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining215aminoacids(22-227a.a.)andhavingamolecularmassof24.5kDa.(MolecularsizeonSDS-PAGEwillappearatapproximately28-40kDa).FCARisexpressedwitha9aminoacidHistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
Sf9,Baculoviruscells.
PhysicalAppearance
Formulation
FCARproteinsolution(0.25mg/ml)containsPhosphateBufferedSaline(pH7.4)and10%glycerol.
StABIlity
Purity
Greaterthan85.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
ADPQEGDFPMPFISAKSSPVIPLDGSVKIQCQAIREAYLTQLMIIKNSTYREIGRRLKFWNETDPEFVIDHMDANKAGRYQCQYRIGHYRFRYSDTLELVVTGLYGKPFLSADRGLVLMPGENISLTCSSAHIPFDRFSLAKEGELSLPQHQSGEHPANFSLGPVDLNVSGIYRCYGWYNRSPYLWSFPSNALELVVTDSIHQDYTTQNHHHHHH.
SafetyDataSheet
SDS