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Other_recombinant_protein >
Prospec/DRG1 Human/Developmentally Regulated GTP Binding Protein 1 Human Recombinant/10µg/PRO-885-10µg

Cataloguenumber
PRO-885
Synonyms
Developmentally-regulatedGTP-bindingprotein1,DRG-1,Neuralprecursorcellexpresseddevelopmentallydown-regulatedprotein3,NEDD-3,DRG1,NEDD3.
Introduction
Developmentally-regulatedGTP-bindingprotein1(DRG1)isamemberoftheGTP1/OBGfamily.DRG1hasaroleincellproliferationanddifferentiation,aswellasinapoptosis,proposingaroleintumorformationandmetastasis.ExpressionoftheDRG1wasconsiderablyreducedinbreasttumorcells,particularlyinpatientswithlymphnodeorbonemetastasisascomparedtothosewithlocalizedbreastcancer.TheDRG1proteinisexpressedathighlevelsintheheart,kidneyandskeletalmuscleandatlowerlevelsinthebrain,liver,placenta,lung,colonandspleen.
Description
DRG1HumanRecombinantproducedinE.Coliisasingle,non-glycosylatedpolypeptidechaincontaining387aminoacids(1-367a.a.)andhavingamolecularmassof42.7kDa.DRG1isfusedtoa20aminoacidHis-tagatN-terminus&purifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
DRG1proteinsolution(0.5mg/ml)containing20mMTris-HClbuffer(pH8.0),1mMDTT,30%glyceroland1mMEDTA.
StABIlity
Storeat4°Cifentirevialwillbeusedwithin2-4weeks.Store,frozenat-20°Cforlongerperiodsoftime.Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).Avoidmultiplefreeze-thawcycles.
Purity
Aminoacidsequence
MGSSHHHHHHSSGLVPRGSHMSSTLAKIAEIEAEMARTQKNKATAHHLGLLKARLAKLRRELITPKGGGGGGPGEGFDVAKTGDARIGFVGFPSVGKSTLLSNLAGVYSEVAAYEFTTLTTVPGVIRYKGAKIQLLDLPGIIEGAKDGKGRGRQVIAVARTCNLILIVLDVLKPLGHKKIIENELEGFGIRLNSKPPNIGFKKKDKGGINLTATCPQSELDAETVKSILAEYKIHNADVTLRSDATADDLIDVVEGNRVYIPCIYVLNKIDQISIEELDIIYKVPHCVPISAHHRWNFDDLLEKIWDYLKLVRIYTKPKGQLPDYTSPVVLPYSRTTVEDFCMKIHKNLIKEFKYALVWGLSVKHNPQKVGKDHTLEDEDVIQIVKK.
SafetyDataSheet
SDS