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Prospec/MAPT Human 383a.a./Microtubule-Associated Protein Tau 383 a.a. Human Recombinant/2µg/PRO-012-2µg

Cataloguenumber
PRO-012
Synonyms
Introduction
MAPTisaneuronalmicrotubuleassociatedproteinlocalizedmostlyonaxons.MAPTpromotestubulinpolymerisationandstABIlizesmicrotubules,howeveritalsoservestoconnectcertainsignallingpathwaystotheCytoskeleton.MAPT,initshyperphosphorylatedform,isthemainpartofpairedhelicalfilaments(PHF)andneurofibrillarylesionsinAlzheimer""sdisease(AD)brain.
Description
MAPTHumanRecombinant(Isoform3)fusedwitha20aminoacidHistagatN-terminusproducedinE.Coliisasingle,non-glycosylated,polypeptidechaincontaining403aminoacids(1-383a.a.)andhavingamolecularmassof42.1kDa(MolecularsizeonSDS-PAGEwillappearhigher).TheMAPTispurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
Stability
Storeat4°Cifentirevialwillbeusedwithin2-4weeks.Store,frozenat-20°Cforlongerperiodsoftime.Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).Pleasepreventfreeze-thawcycles.
Purity
Aminoacidsequence
MGSSHHHHHHSSGLVPRGSHMAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL.
SafetyDataSheet
SDS