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Prospec/HLA-G Human/Major Histocompatibility Complex Class I G Human Recombinant/2µg/PRO-2520-2µg

Cataloguenumber
PRO-2520
Synonyms
MajorHistocompatibilityComplex,ClassI,G,HLA-GHistocompatibilityAntigen,ClassI,G,MHCClassIAntigenG,B2Microglobulin,HLAGAntigen,HLAClassIHistocompatibilityAntigen,AlphaChainG,MutantMHCClassIbAntigen,MutantMHCClassIAntigen,MHCClassIbAntigen,HLA-6.0,MHC-G,HLAG,HLAclassIhistocompatibilityantigen,alphachainG,HLAGantigen,MHCclassIantigenG.
Introduction
HLA-G(MajorHistocompatibilityComplexClassIG)isamemberoftheHLAclassIheavychainparalogues.ThisclassImoleculeisaheterodimerwhichcomprisesaheavychainaswellasalightchain,beta-2microglobulin,whiletheheavychainisfixedinthemembrane.HLA-Gisexpressedonfetalderivedplacentalcells.HLA-Gisanon-classicalclass-IHLAmoleculelinkedwithimmuno-modulatory&anti-inflammatorypropertieswhichinteractswithinhibitoryreceptorssuchas,ILT2/ILT4/KIR2DL4,thatarepresentondifferentimmunecells.HLA-GinhibitstheproliferationofTcells,Bcells&naturalkillercells,moreoveritalsoinducesregulatoryTcells.
Description
HLA-GHumanRecombinantproducedinE.Coliisasingle,non-glycosylatedpolypeptidechaincontaining309aminoacids(25-308a.a)andhavingamolecularmassof35.3kDa.HLA-Gisfusedtoa25aminoacidHis-tagatN-terminus&purifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
HLA-Gproteinsolution(0.25mg/ml)contains20%glycerolandPBS(pH7.4).
StABIlity
Purity
Aminoacidsequence
MGSSHHHHHHSSGLVPRGSHMGSHMGSHSMRYFSAAVSRPGRGEPRFIAMGYVDDTQFVRFDSDSACPRMEPRAPWVEQEGPEYWEEETRNTKAHAQTDRMNLQTLRGYYNQSEASSHTLQWMIGCDLGSDGRLLRGYEQYAYDGKDYLALNEDLRSWTAADTAAQISKRKCEAANVAEQRRAYLEGTCVEWLHRYLENGKEMLQRADPPKTHVTHHPVFDYEATLRCWALGFYPAEIILTWQRDGEDQTQDVELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLMLRWKQSSLPTIPI.
SafetyDataSheet
SDS