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Prospec/LAMP1 Human /Lysosomal-Associated Membrane Protein Human 1 Recombinant/2µg/PRO-2478-2µg
Cataloguenumber
PRO-2478
Synonyms
Lysosome-associatedmembraneglycoprotein1,LAMP1,CD107a,LAMPA,LGP120,LAMP-1,CD107antigen-likefamilymemberA.
Introduction
Lysosomal-AssociatedMembraneProtein1(LAMP1)isapartoftheLAMPfamily.LAMP1isamembraneproteinwhichisexpressedintheendosome-lysosomemembranesofcellsandisimplicatedintumorcellmetastasis.AglycoformofLAMP1isexpressedonthesurfaceofactivatedmacrophagesandpromotesTcellcostimulationandaTh1biasedimmuneresponse.LAMP1isalsofoundontheplasmamembraneduringtheactivationofNKcells,CD8&Tcells,monocytes,basophils,andplatelets.
Description
LAMP1producedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining363aminoacids(29-382a.a.)andhavingamolecularmassof39.4kDa.(MolecularsizeonSDS-PAGEwillappearatapproximately57-70kDa).LAMP1isexpressedwitha9aminoacidHistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
Sf9,Baculoviruscells.
PhysicalAppearance
Sterilefilteredcolorlesssolution.
Formulation
LAMP1proteinsolution(1mg/ml)containsphosphatebufferedsaline(pH7.4)and10%glycerol.
StABIlity
Storeat4°Cifentirevialwillbeusedwithin2-4weeks.Store,frozenat-20°Cforlongerperiodsoftime.Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).Avoidmultiplefreeze-thawcycles.
Purity
Greaterthan90.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
ADPAMFMVKNGNGTACIMANFSAAFSVNYDTKSGPKNMTFDLPSDATVVLNRSSCGKENTSDPSLVIAFGRGHTLTLNFTRNATRYSVQLMSFVYNLSDTHLFPNASSKEIKTVESITDIRADIDKKYRCVSGTQVHMNNVTVTLHDATIQAYLSNSSFSRGETRCEQDRPSPTTAPPAPPSPSPSPVPKSPSVDKYNVSGTNGTCLLASMGLQLNLTYERKDNTTVTRLLNINPNKTSASGSCGAHLVTLELHSEGTTVLLFQFGMNASSSRFFLQGIQLNTILPDARDPAFKAANGSLRALQATVGNSYKCNAEEHVRVTKAFSVNIFKVWVQAFKVEGGQFGSVEECLLDENSMHHHHHH
SafetyDataSheet
SDS
