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Prospec/KLRB1 Human, Sf9/Killer Cell Lectin-Like Receptor Subfamily B, Member 1 Human Recombinant, Sf9/1µg/PRO-2488-1µg

Cataloguenumber
PRO-2488
Synonyms
KillerCellLectinLikeReceptorB1,NaturalKillerCellSurfaceProteinP1A,KillerCellLectin-LikeReceptorSubfamilyB,Member1,C-TypeLectinDomainFamily5MemberB,HNKR-P1A,NKR-P1A,CLEC5B,NKRP1A,KillerCellLectin-LikeReceptorSubfamilyBMember1,CD161Antigen,NKR-P1,CD161,NKR.
Introduction
KLRB1hasaninhibitoryroleonnaturalkiller(NK)cellscytotoxicitywhicharelymphocyteswhofacilitatecytotoxicityandsecretecytokinessubsequenttoimmunestimulation.SomegenesoftheC-typelectinsuperfamily,liketherodentNKRP1familyofglycoproteins,areexpressedbyNKcellsandtakepartinNKcellfunctionregulation.KLRB1holdsanextracellulardomainwithafewcharacteristicmotifsofC-typelectins,atransmembranedomain,andacytoplasmicdomain.DuetoitsexternalCterminusKLRB1isconsideredtobeatypeIImembraneprotein.
Description
KLRB1producedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining401aminoacids(67-225a.a.)andhavingamolecularmassof45.7kDa.(MolecularsizeonSDS-PAGEwillappearatapproximately40-57kDa).KLRB1isexpressedwitha242aminoacidhIgG-His-tagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
Sf9,Baculoviruscells.
PhysicalAppearance
Formulation
KLRB1proteinsolution(0.25mg/ml)containsPhosphateBufferedSaline(pH7.4)and10%glycerol.
StABIlity
Purity
Greaterthan90%asdeterminedbySDS-PAGE.
Aminoacidsequence
ADPQKSSIEKCSVDIQQSRNKTTERPGLLNCPIYWQQLREKCLLFSHTVNPWNNSLADCSTKESSLLLIRDKDELIHTQNLIRDKAILFWIGLNFSLSEKNWKWINGSFLNSNDLEIRGDAKENSCISISQTSVYSEYCSTEIRWICQKELTPVRNKVYPDSLEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH.
SafetyDataSheet
SDS