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Other_recombinant_protein >
Prospec/ITGB4 Human/Integrin Beta 4 Human Recombinant/5µg/PRO-2528-5µg

Cataloguenumber
PRO-2528
Synonyms
Integrinbeta-4,GP150,CD104,ITGB4,IntegrinSubunitBeta4,CD104Antigen,Integrin,Beta4,IntegrinBeta-4.
Introduction
ITGB4(integrinbeta-4isoform1)belongstotheIntegrinbetafamily.ITGB4formsnoncovalentheterodimerswithIntegrinalpha6andtakespartintheformationofepithelialhemidesmosomes.ITGB4hasavitalstructuralroleinthehemidesmosomeofepithelialcellsandisneededfortheregulationofkeratinocytemotility&polarity.ITGB4leanstowardstheassociationwithalpha6subunitandisexpectedtotakeakeyroleintheBIOLOGyofinvasivecarcinoma.
Description
ITGB4producedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining691aminoacids(28-710a.a.)andhavingamolecularmassof77.5kDa.(MolecularsizeonSDS-PAGEwillappearatapproximately70-100kDa).ITGB4isexpressedwithan8aminoacidHistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
ITGB4proteinsolution(0.5mg/ml)containsPhosphateBufferedSaline(pH7.4)&10%glycerol.
StABIlity
Purity
Greaterthan90.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
NRCKKAPVKSCTECVRVDKDCAYCTDEMFRDRRCNTQAELLAAGCQRESIVVMESSFQITEETQIDTTLRRSQMSPQGLRVRLRPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNSDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESAFHYEADGANVLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDSSNIVELLEEAFNRIRSNLDIRALDSPRGLRTEVTSKMFQKTRTGSFHIRRGEVGIYQVQLRALEHVDGTHVCQLPEDQKGNIHLKPSFSDGLKMDAGIICDVCTCELQKEVRSARCSFNGDFVCGQCVCSEGWSGQTCNCSTGSLSDIQPCLREGEDKPCSGRGECQCGHCVCYGEGRYEGQFCEYDNFQCPRTSGFLCNDRGRCSMGQCVCEPGWTGPSCDCPLSNATCIDSNGGICNGRGHCECGRCHCHQQSLYTDTICEINYSAIHPGLCEDLRSCVQCQAWGTGEKKGRTCEECNFKVKMVDELKRAEEVVVRCSFRDEDDDCTYSYTMEGDGAPGPNSTVLVHKKKDCPPGSLEHHHHHH
SafetyDataSheet
SDS