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Other_recombinant_protein >
Prospec/EEF1E1 Human/Eukaryotic Translation Elongation Factor 1 Epsilon 1 Human Recombinant/20µg/PRO-199-20µg

Cataloguenumber
PRO-199
Synonyms
Eukaryotictranslationelongationfactor1epsilon-1,AminoacyltRNAsynthetasecomplex-interactingmultifunctionalprotein3,Elongationfactorp18,Multisynthasecomplexauxiliarycomponentp18,EEF1E1,AIMP3,P18.
Introduction
Eukaryotictranslationelongationfactor1epsilon-1(EEF1E1)sharessequencesimilaritywiththeamino-terminalendsoftheBetaandGammasubunitsofEF-1.ByspecificallyinteractingwithMetRS,EEF1E1bindstoamacromoleculartRNAsynthtasecomplexwhichcatalyzestheligationofspecificaminoacidstotheircognatetRNAs.UponDNAdamage,EEF1E1translocatestothenucleuswhereitinteractswithATMandATR,resultinginp53activation.
Description
EEF1E1producedinE.Coliisasingle,non-glycosylatedpolypeptidechaincontaining194aminoacids(1-174a.a.)andhavingamolecularmassof21.9kDa.EEF1E1isfusedtoa20aminoacidHis-tagatN-terminus&purifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
StABIlity
Storeat4°Cifentirevialwillbeusedwithin2-4weeks.Store,frozenat-20°Cforlongerperiodsoftime.Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).Avoidmultiplefreeze-thawcycles.
Purity
Aminoacidsequence
MGSSHHHHHHSSGLVPRGSHMAAAAELSLLEKSLGLSKGNKYSAQGERQIPVLQTNNGPSLTGLTTIAAHLVKQANKEYLLGSTAEEKAIVQQWLEYRVTQVDGHSSKNDIHTLLKDLNSYLEDKVYLTGYNFTLADILLYYGLHRFIVDLTVQEKEKYLNVSRWFCHIQHYPGIRQHLSSVVFIKNRLYTNSH.
SafetyDataSheet
SDS