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Prospec/EPHB4 Human/EPH Receptor B4 Human Recombinant/20µg/PRO-2592-20µg

Cataloguenumber
PRO-2592
Synonyms
Tyrosine-ProteinKinaseTYRO11,HepatomaTransmembraneKinase,TYRO11,MYK1,HTK,EphrinType-BReceptor,Tyrosine-ProteinKinaseReceptorHTK.
Introduction
EPHB4orEphrintype-Breceptor4isencodedbytheEPHB4geneinhumans.Thereceptoranditsligands(theephrins)takepartindifferentdevelopmentalstages,mainlyinthenervoussystem.EPHB4andotherEphrinreceptorsarethebiggestsubgroupoftheRTKreceptors.EPHB4bindstoephrinB2andhasacrucialpartinthedevelopmentofthevascularsystem.
Description
EPHB4producedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechain(16-539a.a.)andfusedtoan8aaHisTagatC-terminuscontainingatotalof532aminoacidsandhavingamolecularmassof58.1kDa.EPHB4showsmultiplebandsbetween50-70kDaonSDS-PAGE,reducingconditionsandpurifiedbyproprietarychromatographictechniques.
Source
Sf9,Baculoviruscells.
PhysicalAppearance
Formulation
EPHB4proteinsolution(0.25mg/ml)containsPhosphateBufferedSaline(pH7.4)&10%glycerol.
StABIlity
Purity
Greaterthan90.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
LEETLLNTKLETADLKWVTFPQVDGQWEELSGLDEEQHSVRTYEVCDVQRAPGQAHWLRTGWVPRRGAVHVYATLRFTMLECLSLPRAGRSCKETFTVFYYESDADTATALTPAWMENPYIKVDTVAAEHLTRKRPGAEATGKVNVKTLRLGPLSKAGFYLAFQDQGACMALLSLHLFYKKCAQLTVNLTRFPETVPRELVVPVAGSCVVDAVPAPGPSPSLYCREDGQWAEQPVTGCSCAPGFEAAEGNTKCRACAQGTFKPLSGEGSCQPCPANSHSNTIGSAVCQCRVGYFRARTDPRGAPCTTPPSAPRSVVSRLNGSSLHLEWSAPLESGGREDLTYALRCRECRPGGSCAPCGGDLTFDPGPRDLVEPWVVVRGLRPDFTYTFEVTALNGVSSLATGPVPFEPVNVTTDREVPPAVSDIRVTRSSPSSLSLAWAVPRAPSGAVLDYEVKYHEKGAEGPSSVRFLKTSENRAELRGLKRGASYLVQVRARSEAGYGPFGQEHHSQTQLDESEGWREQLAVEHHHHHH.
SafetyDataSheet
SDS