
Cataloguenumber
PRO-317
Synonyms
Introduction
Description
HumanFactorVIIIproducedfromHumanPlasmacontains2332aminoacidsandhavingamolecularmassof330kDa.Factor-VIIIiseffectiveinthecorrectionandpreventionofseverebleedingepisodesattributedtoFactorVIIIdeficiency.
TheFactor-VIIIispurifiedbyproprietarychromatographictechniques.
Source
HumanPlasma.
PhysicalAppearance
Formulation
Thelyophilizedprotein200IU/mlwaslyophilizedfromasterilesolutioncontaining1.5%Glycine,160mMCalciumchlorideand25mMNaCitrateand25mMNaCl.
Solubility
ItisrecommendedtoreconstitutethelyophilizedFactor-VIIIinsterile18MΩ-cmH2Oataconcentrationof200IU/ml,whichcanthenbefurtherdilutedtootheraqueoussolutions.
Makesurethatthevialhasreachedroomtemperaturepriortoitsreconstitution,otherwiseitmightprecipitate.
StABIlity
LyophilizedFactor-VIIIalthoughstableatroomtemperaturefor1week,shouldbestoreddesiccatedbetween2-8°C.UponreconstitutionFactor-VIIIshouldbestoredat4°C.
BIOLOGicalActivity
Thepotencywasfoundtobe10Units/mg.
HumanVirusTest
TheplasmaiscollectedfromdonorswithHepatitisBvaccinated.
EachunitofplasmahasbeentestedforHBsAg,Anti-HIV-1/2plusOandAnti-HCVbyusingtheimportedkitswhichareapprovedbyFederalDrugAdmiNISTration(FDA).
SafetyDataSheet
SDS