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Prospec/Troponin-C2 Human/Troponin-C2 Human Recombinant/20µg/PRO-2572-20µg

Cataloguenumber
PRO-2572
Synonyms
TroponinC,skeletalmuscle,TNNC2.
Introduction
Troponin-C2(TroponinC,skeletalmuscle)isthecentralregulatoryantigenofstriatedmusclecontraction,andmodulatestheCa2+-activationcharacteristicsofmusclefibers.Troponin-C2hasthreesubunits,TroponinI(Tn-1),TroponinT(Tn-T)andTroponinC(Tn-C).Tn-IsubunitinhibitsactomyosinATPaseandTn-TsubunitbindstropomyosinandTn-C,whileTn-Csubunitbindscalciumandovercomestheinhibitoryactionofthetroponincomplexonactinfilaments.Mutationsinallcomponentsofthiscomplexhavebeenlinkedwithskeletalmuscledisease.
Description
Troponin-C2HumanRecombinantproducedinE.Coliisasingle,non-glycosylatedpolypeptidechainof160aminoacidshavingamolecularmassof18.1kDa.TheRecombinantHumanTroponin-C2ispurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
Theprotein(1mg/ml)contains20mMTris-HClbuffer(pH7.5),1mMDTT,100mMNaCland10%glycerol.
StABIlity
Purity
Aminoacidsequence
MTDQQAEARSYLSEEMIAEFKAAFDMFDADGGGDISVKELGTVMRMLGQTPTKEELDAIIEEVDEDGSGTIDFEEFLVMMVRQMKEDAKGKSEEELAECFRIFDRNADGYIDPEELAEIFRASGEHVTDEEIESLMKDGDKNNDGRIDFDEFLKMMEGVQ.
SafetyDataSheet
SDS