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Prospec/AHSG Human HEK/Alpha-2-HS-Glycoprotein Human Recombinant HEK/10µg/PRO-1644-10µg

Cataloguenumber
PRO-1644
Synonyms
Introduction
Fetuinisaliver-producednegativeacutephaseproteincomposedoftwosubunits,theAandBchains.Fetuinhomologshavebeenidentifiedinseveralspeciesincludingrat,sheep,pig,rabbit,guineapig,cattle,mouseandhuman.Multiplephysiologicalrolesforthesehomologshavebeensuggested,includingABIlitytobindtohydroxyapatitecrystalsandtospecificallyinhibitthetyrosinekinase(TK)activityofthereceptor(IR).Fetuin-A(alpha2-Heremans-Schmidglycoprotein;AHSG)isanimportantcirculatinginhibitorofcalcificationinvivo,andisdownregulatedduringtheacute-phaseresponse.Serafrompatientsonlong-termdialysiswithlowAHSGconcentrationsshowedimpairedex-vivocapacitytoinhibitCaxPO4precipitation.Fetuinmayinfluencetheresolutionofinflammationbymodulatingthephagocytosisofapoptoticcellsbymacrophages.ASHGblocksTGF-beta-dependentsignalinginosteoblasticcells,andmicelackingASHGdisplaygrowthplatedefects,increasedboneformationwithage,andenhancedcytokine-dependentosteogenesis.
Description
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