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Prospec/HERV-K/Endogenous retrovirus K Envelope Human Recombinant/100µg/HER-001-100µg

Cataloguenumber
HER-001
Introduction
HERVKisrelatedwithseveraltumorssuchaspassengervirus,andanti-Retroviraltherapyagainstamyotrophiclateralsclerosis/ALShasexhibitedtodecreasethesymptomsofamyotrophiclateralsclerosis/ALS.Highcountsofviralsequencesexistinthehumangenomebutstaysilent.Though,inpathologicalconditions,thesevirusesareproduced.HumanEndogenousRetrovirus-K,isproducedinneuronsofasubpopulationofpatientswithamyotrophiclateralsclerosis/ALS,aprogressiveneurodegenerativedisease.TheenvelopeproteinofthisHERVresultsindegenerationofneurons,andtransgenicanimalsproducingthisproteinadvanceanALS-likesyndrometriggeredbynucleolardysfunctioninmotorneurons.ReactivationoftheHERVKiscontrolledbythetranscriptionfactorTDP-43.Therefore,therapeutictacticsagainstthisvirusalterthecourseofthedisease.
Description
TheE.ColiderivedHERV-KrecombinanttruncatedproteinisfusedtoaSixhistidinetagatC-terminusandhasaMWof51.5kDa(pI9.06).
Source
EscherichiaColi.
Purity
Proteinis>90%pureasdeterminedbySDSPAGE.
PhysicalAppearance
SterileFilteredclearsolution.
Formulation
10mMTris-HCl,pH7.2.
StABIlity
HERV-Kalthoughstableat4°Cfor1week,shouldbestoredbelow-18°C.
Pleasepreventfreezethawcycles.
Aminoacidsequence
MWTVPSFTNDSYQVYNVFSTNSFQLLTVKRTPHEAWRVPLTTKTNKTKGLPDCPKKPTNGPFIVTSILWDNCNAPKAVVLQTLAMGIVIDWAPKGHYWQDCSSKNTLCSEFIYSLDYIEHGWQSYTMRQRVSPYPFKWMDTGIAPPRPKIIHPFFTPEHPELWKLAAALSGIKIWNTTYQLLRTKTKTPTFNITLISEWVIPIRSCVKPPYMLLVGNIIMMPDAQTIECHNCKLFTCIDATFNPTTSILLVRAREGVWIPVSLHRPWESSPSIHIVNEVLKDILKRTKRFIFTLIAVLAGLLAVTATAATAGVAIRSSVQTAHYVEACQKNSSRLWNSQAQIDQKLANQINDLRQSVTWLGDRVMNLQHRMQLQCDWNTSDYCITPYAYNQDQHSWENVSRHLKAWDDNLTLDISQLKEQIFEASQAHLSTVPGSHIFEGITKQLPDFNPFKWLKPVRGSLLLLALLILVCLCCLLLVCRCL.
Applications
DetectionofHumanEndogeniousRetrovirusKinindividualsisuntested.
SafetyDataSheet
SDS
Usage
Prospec"sproductsarefurnishedforLABORATORYRESEARCHUSEONLY.Theymaynotbeusedasdrugs,agriculturalorpesticidalproducts,foodadditivesorhouseholdchemicals.