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Prospec/CMV Pp65, 561 a.a./Cytomegalo Virus Pp65(UL83), 561 a.a.Recombinant/500µg/CMV-218-500µg

Cataloguenumber
CMV-218
Introduction
CMVispartoftheBetaherpesvirinaesubfamilyofHerpesviridae;includingherpessimplexvirustypes1and2,varicella-zostervirus,andEpstein-Barrvirus.TheherpesviruseshasthecommonABIlitytostaylatentoverlongperiodsoftime.CMVhasthelargestgenomeoftheherpesviruses,rangingfrom230-240kilobasepairs.CMVisadouble-strandedlinearDNAviruswith162hexagonalproteincapsomeressurroundedbyalipidmembrane.HumanCMViscomposedofuniqueandinvertedrepeatsthatincludetheexistenceof4genomeisomerscausedbyinversionofL-Sgenomecomponents(classE).Replicationmaybedividedintoimmediateearly,delayedearly,andlategeneexpressionbasedontimeofsynthesisafterinfection.TheDNAisreplicatedbyrollingcircles.Invitro,CMVreplicatesinhumanfibroblasts.
Description
TheE.Coliderived62.8kDarecombinantproteincontainstheCMVPp65(UL83)immunodominantregions,having561aminoacids.
Source
PurificationMethod
Purity
Formulation
25mMTris-HclpH8,5mMbMe,8MUrea.
Stability
CMVPp65proteinalthoughstableat4°Cfor1week,shouldbestoredbelow-18°C.Pleasepreventfreezethawcycles.
Specificity
Applications
References
Title:Cytomegalovirus-InfectedHumanEndothelialCellsCanStimulateAllogeneicCD4+MemoryTCellsbyReleasingAntigenicExosomesPublication:Endocrinology150.7(2009):3252-3258.Link:http://www.jimmunol.org/content/182/3/1548.full
SafetyDataSheet
SDS